"Signal averaged ECG with detailed analysis of QRS duration and late potentials is a very valuable tool in stratifying patients at risk of cardiac death. MADIT II type patients with normal QRS duration and lack of late potentials are at relatively low risk of subsequent cardiac events. The very high negative predictive value of SAECG might help prioritize patients for ICD therapy. We are glad to have the opportunity to test the predictive value of SAECG in a prospective cohort of MADIT II type patients who are undergoing several other tests simultaneously. It is likely that SAECG and Microvolt T-Wave Alternans tests will emerge as routine for identifying low-risk and high-risk patients considered for ICD therapy."

Wojciech Zareba, MD, PhD, University of Rochester Medical School

Principal Investigator for National Institutes for Health funded investigation into "Risk Stratification in MADITT II Type Patients."